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According to the Centers for Disease Control and Prevention (CDC), the nicotine level in your blood can drop to zero When you ingest tobacco, your liver breaks down nicotine into a substance called cotinine before all traces are removed from the body via the urine

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Moreover, the competitive selective nACh receptor antagonist hexamethonium inhibited sensory nerve stimulation in response to TS, but had no effect on other tussive stimuli, indicating a role for nicotine in the smoke-induced irritant response in dogs (Lee et al., 1983, 1985, 1986, 1989